Miramar Police and friends and family of Vilet Torrez handed out flyers near her home Tuesday.
They went to nearby communities and shopping centers searching for information about the missing mother of three.
The 38-year-old woman was reported missing last Monday, but hasn't been seen since Friday, March 30.
"It feels like a dream. We're totally destroyed," Torrez brother Javier Blanco said. "I feel like I've lost faith in humanity. I don't know what happened ... and something happened."
After executing a search warrant at Torrez's home and looking through nearby surveillance video, police said they still have no leads and no suspects.
However, Blanco said he is skeptical of his sister's husband, Cid Torrez, saying, "I still haven't seen Cid out here. I'm still unclear why a lawyer was retained by him."
The Florida Department of Children and Families temporarily removed the three children of Vilet and Cid Torrez from their father's custody last week following a confidential call to the Florida Abuse Hotline, according to a DCF spokesman.
Cid Torrez left a Broward courtroom in tears after a judge confirmed that decision Friday, and his attorney said "this is not fair treatment, there is no indication that anything untoward has happened to Mr. Torrez's estranged wife."
Meantime, family members are holding out hope Vilet Torrez will be found safely. While they search for answers, they are also looking after her children, who are all under the age of 12.
"They are precious, innocent little kids and all we're doing is making sure they feel loved and safe," said Torrez's sister-in-law, Julie Blanco.
If you have any information, call Broward County Crime Stoppers at 954-493-TIPS.