The interview will air Tuesday, May 25 at 11:35 PM, and feature the reality star discussing his recent stint in rehab and the allegations of cheating that led to the Oscar winner filing for divorce.
Jesse will also address the former couple's adoption of baby Louis, whom he has since ceded his custody of.
Though he has avoided interviews, Jesse has released a number of statements since the cheating allegations first made headlines in March.
"My whole life has been full of hard decisions," Jesse said in a statement to People in April. "The decision to let my wife end our marriage, and continue the adoption of Louis on her own, has been the hardest. The love I have for Louis cannot be put to words. Not having him around to love and to hold has left a huge hole in my heart."
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