The 47-year-old actor bested his fellow stars to take home the title and win the lion's share of the donation money for his chosen charity, Art Has Heart, a non-profit aimed at providing college scholarships for needy high school students.
Lou beat out former pro-wrestler Torrie Wilson, who came in second while ex-NBA star John Salley came in third.
Wednesday night's show became a reunion of sorts for most of the cast, with the exception of the Angela Shelton and Frances Callier of comedy duo Frangela, who were noticeably absent.
Heidi and Spencer Pratt, however, did appear with the stars that reassembled in the jungle for the finale.
During an interview with show hosts Damien Fahey and Myleene Klaas, Heidi said she is doing fine following the hospitalization that led to her ultimate exit from the jungle earlier this month.
"I'm not throwing up, I'm a lot better," she said. "The doctor said I'll be OK if I stay out of the jungle."
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