Here are the most important news, trends and analysis that investors need to start their trading day:

• Stocks set to open mixed after Dow fell from record high
• 10-year Treasury yield dips after ADP private jobs report
• Pfizer says Covid vaccine 100% effective in kids ages 12 to 15
• Biden set to unveil his $2 trillion infrastructure plan
• College athlete compensation case comes before Supreme Court

1. Stocks set to open mixed after Dow fell from record high

U.S. stock futures were mixed Wednesday, one day after the Dow Jones Industrial Average fell 0.3%, breaking a three-session winning streak and slipping from its previous record high close. The S&P 500 and Nasdaq also dropped slightly as tech stocks came under pressure after the 10-year Treasury yield hit a new 14-month high of 1.776% on Tuesday.

Heading into the last day of March, the Dow and S&P 500 were sitting on solid gains for the month and all of the first quarter. The Nasdaq was tracking for a March loss but a modest quarterly gain. The 10-year Treasury yield soared about 18% in March and about 88% for the quarter.

2. 10-year Treasury yield dips after ADP private jobs report

The 10-year Treasury yield dipped but held around 1.72% on Wednesday morning after the ADP's monthly look at jobs trends at U.S. companies showed 517,000 positions were added in March. Despite coming in slightly below estimates, it was the fastest pace since September and well above February's disappointing 176,000.

As of late, the ADP report has not been a great indicator of what the government's monthly employment data might show. The March jobs report is set for release Friday despite the Good Friday holiday closure of the stock market.

3. Pfizer says Covid vaccine 100% effective in kids ages 12 to 15

Pfizer said Wednesday a new study shows its coronavirus vaccine was 100% effective in adolescents ages 12 to 15. The U.S. drug giant, which developed the two-shot regimen in partnership with Germany's BioNTech, plans to submit the new data to the FDA "as soon as possible," CEO Albert Bourla said in a statement. Kids in that age group could be eligible for the vaccine before the new school year in the fall.

Pfizer's vaccine has already been authorized for emergency use in the U.S. for people 16 and older. The two other Covid vaccines allowed in the U.S., Moderna's two-shot vaccine and Johnson & Johnson's one-shot vaccine, have been cleared for ages 18 and older.

4. Biden set to unveil his $2 trillion infrastructure plan

President Joe Biden will unveil a more than $2 trillion infrastructure and economic recovery package Wednesday. The plan aims to revitalize U.S. transportation infrastructure, water systems, broadband and manufacturing, among other goals. An increase in the corporate tax rate to 28% and measures designed to prevent the offshoring of profits will fund the spending, according to the White House. Biden hopes the package will create manufacturing jobs and rescue failing American infrastructure as the country tries to emerge from the shadow of Covid.

5. College athlete compensation case comes before Supreme Court

The Supreme Court on Wednesday is set to hear arguments from the National Collegiate Athletic Association in a case over whether the organization can cap education-related benefits paid to college athletes. Against the backdrop of the NCAA's men's and women's basketball tournaments, the case comes as broader debate rages over compensation for student athletes. Some of players in the March Madness games have sought to pressure the NCAA over its compensation policies, using the hashtag #NotNCAAProperty.

— Get the latest on the pandemic with CNBC's coronavirus blog.