Evgenii Dadonov had a goal and two assists, while Aleksander Barkov had a goal and a helper and Sam Montembeault made 34 saves.
Aleksander Barkov had a goal and an assist for Florida as Evgenii Dadonov, Brett Connolly and Frank Vatrano also scored
Florida trailed 3-1 with around eight minutes remaining when Aleksander Barkov picked a good spot for his first goal of the season, a power-play tally that started the Panthers on the comeback trail.
J.T. Miller had two goals Monday night, including his 100th in the NHL, and Vancouver scored five times in the first period on its way to a 7-2 victory
The Panthers are on a six-game points streak, and four of their past five have gone past regulation as Huberdeau has 10 points in his last eight games.
The Panthers have gone to overtime in four of their eight games this season and lost the previous three, two in a shootout and one in overtime.
Sergei Bobrovsky allowed four goals on 14 shots before being replaced by Sam Montembeault to start the second period.
Owen Tippett, Anthony Greco, Jonathan Ang and Brett Connolly scored for Florida as Vincent Trocheck scored the Panthers' only goal in the shootout.
Evgenii Dadonov, Mike Hoffman and Jonathan Huberdeau had goals for Florida, while Chris Driedger finished with 15 saves.
Sergei Bobrovsky and Florida's three other free agent signings — defenseman Anton Stralman, and forwards Brett Connolly and Noel Acciari — put on their new Panthers sweaters for the first time Tuesday.