The night's main event will be The Rock vs. John Cena, in what the WWE is calling "the most anticipated clash in history," according to the WWE website.
Other matchups include CM Punk vs. Chris Jericho, The Undertaker vs. Triple H and Daniel Bryan vs. Sheamus.
The annual event is expected to draw more than 70,000 people from all 50 states and 30 different countries, the WWE said.
Other events leading up to WrestleMania XXVIII began in South Florida on Thursday.
WrestleMania XXVIII starts at 6: 30 p.m.