Now, he's hitting the reality TV circuit.
Timberlake's new reality show, "The Phone," challenges contestants via cell phone to complete missions that could earn them a $50,000 prize. It premieres Tuesday night at 10 p.m. on MTV.
"The Phone" is an updated remake of a similar program based out of the Netherlands - Timberlake says his revved-up version, with high-octane thrills and crazy stunts, is like the Holland show "on acid."
"We take four people and put them through a game of hell, basically," Timberlake, 28, told People magazine.
Among the tasks? Climbing to the top of Seattle's Space Needle and blowing up a car.
"We make them characters in an action film. We constantly throw a curve ball," Timberlake said.
Timberlake, who's producing the show, helped develop the six-episode series earlier this year.
The pop star will also guest-host Saturday Night Live on May 9.